home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Software Vault: The Diamond Collection
/
The Diamond Collection (Software Vault)(Digital Impact).ISO
/
cdr16
/
med9505a.zip
/
M9550221.TXT
< prev
next >
Wrap
Text File
|
1995-03-04
|
2KB
|
38 lines
Document 0221
DOCN M9550221
TI Autoimmune phenomena in children with human immunodeficiency virus
infection and acquired immunodeficiency syndrome.
DT 9505
AU Rodriguez-Mahou M; Lopez-Longo J; Lapointe N; Carreno L; Grau R;
Gurbindo D; Fernandez-Cruz E; Department of Immunology, Hospital General
Universitario Gregorio; Maranon, Madrid, Spain.
SO Acta Paediatr Suppl. 1994 Aug;400:31-4. Unique Identifier : AIDSLINE
MED/95135015
AB We have studied sera from 44 children with Human Immunodeficiency Virus
infection and Acquired Immunodeficiency Syndrome using immunoblotting,
radioimmunoassay, enzymoimmunoassay and indirect immunofluorescence. We
have detected a low incidence of antinuclear (2.9%), anti-reticulin
(2.9%) and anti-smooth muscle (14.7%) antibodies by indirect
immunofluorescence. By enzymoimmunoassay we have detected anti-dsDNA
(20.5%) and anti-ENA [anti-nRNP (61.3%), anti-Sm (29.5%), anti-Ro
(47.7%) and anti-La (18.1%)] antibodies. Tests for anti-dsDNA by
radioimmunoassay were negative, suggesting the presence of low-avidity
anti-DNA antibodies. By immunoblotting we have detected anti-C (nRNP)
(33.3%), anti-BB' (Sm) (33.3%), anti-Ro (60 KD) (4.5%) and anti-La
(11.3%) antibodies. The presence of anti-Ro antibodies was associated
with progressive neurological disease. Long-term follow-up studies with
larger numbers of patients are necessary to evaluate the clinical
significance of the presence of anti-dsDNA and anti-ENA antibodies in
children infected with Human Immunodeficiency Virus.
DE Acquired Immunodeficiency Syndrome/BLOOD/GENETICS/IMMUNOLOGY
Antibodies, Antinuclear/BLOOD/IMMUNOLOGY
Autoantibodies/BLOOD/*IMMUNOLOGY *Autoimmunity Case-Control Studies
Child Child, Preschool DNA, Viral/*ANALYSIS Follow-Up Studies Human
HIV Infections/BLOOD/GENETICS/*IMMUNOLOGY *HIV-1 Infant
Isoantibodies/BLOOD/IMMUNOLOGY Polymerase Chain Reaction
Ribonucleoproteins, Small Nuclear/BLOOD/IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).